The NuRD complex componentp66suppresses photoreceptor neuron regeneration in planarians
نویسندگان
چکیده
منابع مشابه
The NuRD complex component p66 suppresses photoreceptor neuron regeneration in planarians
Regeneration involves precise control of cell fate to produce an appropriate complement of tissues formed within a blastema. Several chromatin-modifying complexes have been identified as required for regeneration in planarians, but it is unclear whether this class of molecules uniformly promotes the production of differentiated cells. We identify a function for p66, encoding a DNA-binding prote...
متن کاملRegeneration: Organizing the Blastema in Planarians
The processes that trigger regeneration after injury and link new and old tissue are not fully understood. New findings indicate that, after decapitation, planarians build an organizing center from stem cells at the old midline that directs head patterning and outgrowth.
متن کاملRegeneration and pattern formation in planarians
In planarians, blastema cells do not divide, and growth of blastema is thought to result from the steady accumulation, beneath the wound epithelium, of undifferentiated cells produced by cell division in the stump. However, whether these cells come only from local stump sources or whether cells placed far from the wound can also participate, after long-range migrations, in the growth of blastem...
متن کاملStem cells and regeneration in planarians.
Understanding stem cells is a major goal of current research because of its potential medical applications. Although great advances have been made, such as the culturing and differentiation of embryonic stem cells and reprogramming of cell fates, many basic questions remain unanswered. Describing the mechanisms underlying regeneration will help to understand the biology of stem cells and theref...
متن کاملS19-01 Planarians, stem cells, and regeneration
ical role in regulating their entry into the myogenic programme. We had shown that in the Pax3/7 double mutant the myogenic determination genes, Myf5 and MyoD are not activated, leading to a major deficit in skeletal muscle. Pax3 directly activates Myf5, thus promoting a myogenic cell fate. However, it is essential to maintain a balance between differentiation and renewal of the progenitor cell...
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ژورنال
عنوان ژورنال: Regeneration
سال: 2016
ISSN: 2052-4412
DOI: 10.1002/reg2.58